Finasteride 98319-26-7

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Molecular Weight:

372.54 Finasteride is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).

Biological Activity

Finasteride
binds to the type 2 isozyme-NADPH complex to form a ternary complex
with Ki of 1.19 nM, which then rearranges to a high affinity complex
(E:I) with a pseudo first order rate constant of 1.62 ms. Finasteride dose-dependently inhibits the growth rate of the LnCap cell line. Finasteride markedly inhibits prostate-specific antigen (PSA) secretion and expression in LNCaP cells.


Finasteride induces dosage-related incidences of hypospadias
(penischisis) in male offspring with a threshold dosage level near 0.1
mg/kg/day and a 100% effect level of 100 mg/kg/day in male rats.
Finasteride also causes decreased anogenital distance in male offspring
in male rats. Finasteride and castration decreases
prostate weight at day 21 by 65% and 93%, respectively, in rats.


Finasteride has no significant effect on DNA content after 4 days and
decreases DNA content by a maximum of 52% at 14 days in rats.
Finasteride causes a less intense increase in staining in which 16% of
epithelial cells stained for tissue transglutaminase on day 9 with a
return to baseline by day 14 in rats. Finasteride-induced staining is
less intense with peak staining at day 4 (0.7% of epithelial cells) and a
return to control values by day 9 in rats.

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Product Categories : Endocrinology & Hormones > 5-alpha Reductase Inhibitor