BMY 7378 21102-95-4

.cp_wz table {border-top: 1px solid #ccc;border-left:1px solid #ccc; } .cp_wz table td{border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc;border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;}


Molecular Weight:

458.42 BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.

Biological Activity

BMY 7378 shows 10-fold selectivity for α2C-adrenoceptors over other α2-adrenoceptors with pKi of 6.54. BMY 7378 is selective for the α1D-adrenoceptor subtype (PKi: hamster α1b-adrenoceptor 6.2, human α1b-adrenoceptor 7.2; bovine α1c-adrenoceptor 6.1, human α1c-adrenoceptor 6.6; rat α1d-adrenoceptor 8.2, human α1d-adrenoceptor 9.4 BMY 7378 at concentration of 1 nM to 30 nM elicits inhibitory effects
in a concentration-dependent manner in the rat dorsal raphe nucleus.


BMY 7378 (pA2 of 8.67) is approximately 100 times more potent than yohimbine (pA2 of 6.62) against contractions to noradrenaline in rat aorta. BMY 7378 (pA2 of 6.48) is approximately 10 times less potent than yohimbine (pA2 of 7.56) at antagonizing the contractile response to noradrenaline in human saphenous vein (α2C-adrenoceptor).


BMY 7378 dose dependently (0.25-5 mg/kg s.c.) reduces the undetectable
levels forepaw treading and head weaving induced by 8-OH-DPAT (0.75
mg/kg s.c.) in rats. BMY 7378 causes a marked and dose-dependent
(0.01-1.0 mg/kg s.c.) decrease of 5-HT release in ventral hippocampus of
the anaesthetized rat as detected by brain microdialysis in rats.

Contact us if you need more details on 21102-95-4. We are ready to answer your questions on packaging, logistics, certification or any Other aspects about BMY 7378 21102-95-4、21102-95-4 BMY 7378. If these products fail to match your need, please contact us and we would like to provide relevant information.

Product Categories : Neuronal Signaling > 5-HT Receptor Inhibitor