Fluoxetine HCl 56296-78-7

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Molecular Weight:

345.79 Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.

Biological Activity

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus
of the hippocampus of adult rat. Fluoxetine also increases the number of
proliferating cells in the prelimbic cortex.


Fluoxetine
accelerates the maturation of immature neurons. Fluoxetine enhances
neurogenesis-dependent long-term potentiation (LTP) in the dentate
gyrus. Fluoxetine, but not citalopram, fluvoxamine,
paroxetine and sertraline, increases norepinephrine and dopamine
extracellular levels in prefrontal cortex.


Fluoxetine produces robust
and sustained increases in extracellular concentrations of
norepinephrine and dopamine after acute systemic administration.


Fluoxetine treatment also reverses the deficit in escape latency
observed in animals exposed to inescapable shock in adult male
Sprague–Dawley rats. Fluoxetine combined with Olanzapine
produces robust, sustained increases of extracellular levels of dopamine
([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the
baseline, respectively, which are significantly greater than either drug
alone.

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