Hexamethonium Bromide 55-97-0

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Molecular Weight: 362.19 Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.



Hexamethonium Bromide is effective against Ach and carbachol (CCh) on
the amplitude of endplate responses of rat omohyoid muscle with EC50 of
300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM)
causes an increase in the amplitude of nerve-evoked endplate currents
(e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium
Bromide is also a weak inhibitor of acetylcholinesterase activity in rat
muscle homogenates with EC50 of 1.5 mM. Hexamethonium
Bromide (200 μM) decreases the time constant of decay of both endplate
currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs)
(by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of
stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c.
quantal content by 30-40%.





Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	362.19
Formula	C12H30N2.2Br
CAS No.	55-97-0

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	<1 mg/mL (
		Water	73 mg/mL (201.55 mM)
		Ethanol	<1 mg/mL (
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2)

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Product Categories : Neuronal Signaling > AChR Inhibitor