Decamethonium Bromide 541-22-0

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Molecular Weight: 418.29 Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.



Decamethonium (Syncurine) is a depolarizing muscle relaxant or
neuromuscular blocking agent, and is used in anesthesia to induce
paralysis. Decamethonium, which has a short action time, is similar to
acetylcholine and acts as a partial agonist of the nicotinic
acetylcholine receptor. In the motor endplate, it causes depolarization,
preventing further effects to the normal release of acetylcholine from
the presynaptic terminal, and therefore preventing the neural stimulus
from affecting the muscle. In the process of binding, decamethonium
actually activates (depolarizes) the motor endplate, but since the
decamethonium itself is not degraded, the membrane remains depolarized
and unresponsive to normal acetylcholine release.




Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	418.29
Formula	C16H38N2.2Br
CAS No.	541-22-0

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	34 mg/mL (81.28 mM)
		Water	84 mg/mL (200.81 mM)
		Ethanol	25 mg/mL (59.76 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)

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Product Categories : Neuronal Signaling > AChR Inhibitor