Doxazosin Mesylate 77883-43-3

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Molecular Weight: 547.58 Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.

Biological Activity

Doxazosin-induced Apoptosis is blocked by specific caspase-8 Inhibitors,
supporting the functional involvement of caspase-8 in doxazosin-induced
apoptosis. Doxazosin increases FADD recruitment and subsequent
caspase-8 activation, implicating Fas-mediated apoptosis as the
underlying mechanism of the effect of Doxazosin in prostate cells. Doxazosin and cholestyramine similarly decreases plasma total and LDL
plus VLDL cholesterols, and total triglycerides on average by 46%, 61%
and 45% respectively. Doxazosin induces DNA Damage and
cell death in HL-1 cell line. Doxazosin treatment decreases cell
viability in primary cultures of neonatal rat cardiomyocytes, and
Hoechst dye vital staining demonstrates doxazosin-induced apoptosis in
primary cultures of human adult cardiomyocytes.


Doxazosin
antagonizes the VEGF-mediated angiogenic response of HUVEC cells, by
abrogating cell adhesion to fibronectin and collagen-coated surfaces and
inhibiting cell migration, via a potential downregulation of VEGF
expression.

Doxazosin also reduces mean arterial pressure by 18% without affecting heart rate in all hamsters. Doxazosin causes a significant reduction in the wet weight of BabeTGF-beta 1-infected mouse prostate reconstitution (MPR).

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Product Categories : Neuronal Signaling > Adrenergic Receptor Inhibitor