Chloroquine Phosphate 50-63-5

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Molecular Weight: 515.86 Chloroquine Phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.


Chloroquine is a chemotherapeutic agent for the clinical treatment of
malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication
and RNA synthesis which in turn results in cell death. The effect of
Chloroquine may also be related to the formation of a toxic
heme-Chloroquine complex. Chloroquine inhibits trophozoite hemoglobin
degradation through increasing vacuolar pH and inhibiting the activity
of vacuolar phospholipase, vacuolar Proteases, and heme polymerase. Chloroquine possesses definite antirheumatic properties.


Chloroquine
has immuno-modulatory effects, suppressing the production/release of
tumour necrosis factor and interleukin 6. Moreover, Chloroquine exerts
direct antiviral effects, inhibiting pH-dependent steps of the
replication of several viruses including members of the flaviviruses,
retroviruses, and coronaviruses. Its best-studied effects are those
against HIV replication. Chloroquine can accumulate
inside the macrophage phagolysosome by ion trapping where it exerts
potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C. neoformans.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	515.86
Formula	C18H26ClN3.2H3O4P
CAS No.	50-63-5

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	<1 mg/mL (
		Water	100 mg/mL (193.85 mM)
		Ethanol	<1 mg/mL (
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, phosphate (1:2)

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