Golgicide A 1139889-93-2

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Molecular Weight:

284.3 Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

Biological Activity

Golgicide A inhibits the effect of shiga toxin on protein synthesis with
an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1
activation, arrests secretion of soluble and membrane-anchored Proteins
and then impairs retrograde toxin transport. Golgicide A
decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition,
Golgicide A causes redistribution of NS5A and accumulation of infectious
viral particles in J6/JFH1 cells.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	284.3
Formula	C17H14F2N2
CAS No.	1139889-93-2

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	N/A

Solubility (25°C) *	In vitro	DMSO	57 mg/mL (200.49 mM)
		Water	<1 mg/mL (
		Ethanol	4 mg/mL (14.06 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-rel-

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Product Categories : Transmembrane Transporters > ATPase Inhibitor