Nicardipine HCl 54527-84-3

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Molecular Weight:

515.99 Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.

Biological Activity

Nicardipine (100 mg/kg) produces a significant transient decrease in
retinal blood flow in cats. Nicardipine (100 mg/kg) produces a
significant increase in ONH blood flow despite a significant decrease of
the mean arterial blood pressure in cats, which suggests that
nicardipine could have a beneficial effect on ONH tissue. Nicardipine significantly reduces systolic pressure in the
spontaneously hypertensive rats (SHR).


Nicardipine significantly reduces
the thickness of the tunica media, the media: lumen ratio and increases
the luminal area, primarily at the level of small pial arteries and of
intracerebral arteries in the spontaneously hypertensive rats (SHR).
Nicardipine increases the number of neurones in the frontal cortex and
in the occipital cortex of SHR and counters hyperplasia and hypertrophy
of GFAP-immunoreactive astrocytes. Nicardipine increases the number of
neurones in the CA1 field of the hippocampus and decreases the number
and the size of astrocytes of the white matter and grey matter,
respectively.


Nicardipine (40 mg/kg twice daily for 8
weeks) reduces plaque area by 49.2% in cholesterol-fed rabbits.
Nicardipine (40 mg/kg) reduces cholesterol accumulation in the aortic
arch by 74.5% in cholesterol-fed rabbits. Nicardipine (5
mg/kg) combined with Nimodipine (80 mg/kg) and Flunarizine(80 mg/kg)
results in a significant enhancement of the protective potency of either
ethosuximide (50 mg/kg) or valproate (100 mg/kg) against clonic
seizures in mice.

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Product Categories : Transmembrane Transporters > Calcium Channel Inhibitor