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KN-93 Phosphate 1188890-41-6

Product Description

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Molecular Weight:

599.03 KN-93 Phosphate is a potent and specific inhibitor of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.

Biological Activity

KN-93 inhibits dopamine formation in PC12h cells by modulating the
reaction rate of TH to reduce the Ca(2+)-mediated phosphorylation levels
of the TH molecule. KN-93 inhibits serum-induced fibroblast cell growth with IC50 of 8 μM, and induces Apoptosis after prolonged G1 arrest. KN-93 inhibits androgen receptor activity and p53-independently induces cell death in PCa cells.


KN-93 (5 μg) ameliorates levodopa-induced dyskinesia by lowering the
expression of pGluR1S845 in a rat model of Parkinson`s disease. In MRL/lpr Foxp3-GFP mice, KN-93 results in a significant induction of
Treg cells in the spleen, peripheral lymph nodes and peripheral blood,
and decreases skin and kidney damage.

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Product Categories : Neuronal Signaling > CaMK Inhibitor