KN-62 127191-97-3

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Molecular Weight:

721.84 KN-62 is a potent and specific inhibitor of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) with Ki of 0.9 μM.

Biological Activity

KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells.


KN-62 (10 μM) inhibits carbachol and potassium-stimulated insulin secretion from rat pancreatic islets.


KN-62 also inhibits growth of K562 cells and blocks Cell Cycle progression.


KN-62 inhibits seizure-induced expression of brain-derived neurotrophic factor mRNA in adult rat brain.


Kinase assay

Total kinase activity of CaMKII, determined in a standard 2 min assay (100 μL), contained 35 mM HEPES, 10 mM MgCl2, 1 mM CaCl2, 10 μg of chicken gizzard myosin 20-kD light chain, 0.1 μM calmodulin, and 10 μM [γ-33]ATP at 30 °C. The kinase reaction is halted by adding 1 mL of 10% trichloroacetic acid.

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Product Categories : Neuronal Signaling > CaMK Inhibitor