Product Description
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Molecular Weight:
360.9 Dorzolamide HCl is a Carbonic Anhydrase Inhibitor.
Biological Activity
Dorzolamide HCl is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. Dorzolamide HCl is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
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Contact us if you need more details on 130693-82-2. We are ready to answer your questions on packaging, logistics, certification or any Other aspects about Dorzolamide HCl 130693-82-2、130693-82-2 Dorzolamide HCl. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight:
360.9 Dorzolamide HCl is a Carbonic Anhydrase Inhibitor.
Biological Activity
Dorzolamide HCl is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. Dorzolamide HCl is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
| Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
| Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
| Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
| Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
| rat Km(6) |
Chemical Information
| Molecular Weight (MW) | 360.9 |
|---|---|
| Formula | C10H16N2O4S3.HCl |
| CAS No. | 130693-82-2 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in solvent (DMSO, water, etc.) | |
| Synonyms | MK-507 (L-671152) HCl |
| Solubility (25°C) * | In vitro | DMSO | <1 mg/mL ( |
|---|---|---|---|
| Water | 14 mg/mL (38.79 mM) | ||
| Ethanol | <1 mg/mL ( | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride |
|---|
Molarity Calculator
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Contact us if you need more details on 130693-82-2. We are ready to answer your questions on packaging, logistics, certification or any Other aspects about Dorzolamide HCl 130693-82-2、130693-82-2 Dorzolamide HCl. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Metabolism > Carbonic Anhydrase Inhibitor
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