467.49 Z-VAD-FMK is a cell-permeable, irreversible pan-Caspase Inhibitor, blocks all features of Apoptosis.
Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM)
inhibits activation of PARP protease activity in control THP.1 cell
lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact
THP.1 and Jurkat cells. Z-VAD-FMK (50 μM) cotreatment
abolishes the apoptotic morphology of camptothecin-treated HL60 cells.
Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60
cells. Z-VAD-FMK (50 μM) inhibits cell death following
dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases
the percentage of transfected cells surviving from 26% to 63% in S2
cells. Z-VAD-FMK (> 100 μM) enhances TNFα-induced
neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks
TNFα-stimulated apoptosis in human neutrophils.
(10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK
(10 mM) inhibits apoptosis in anterior stromal keratocytes detected with
the TUNEL assay.
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