MG-101 (ALLN) 110044-82-1

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Molecular Weight:

383.53 MG-101 (ALLN) is a cell-permeable and Potent Inhibitor of cysteine Proteases including calpains and lysosomal cathepsins.






Biological Activity


MG-101 (ALLN) effectively inhibits cysteine proteinases with ID50 of 7
nM and 13 nM for cathepsins L and B, respectively. MG-101 (ALLN) shows
very weak inhibitory activities towards cathepsin D (aspartic protease)
and subtilisin (serine protease).


MG-101 thus transforms NIH3T3 cells
and also induces differentiation of PC12 pheochromocytoma cells. MG-101, as an inhibitor of Ca(2+)-dependent cysteine proteases,
inhibits the degradation of HMG-CoA reductase and HMGal in cholesterol
biosynthesis.


In HCT116 cells, MG-101 decreases cell
viability and tumor growth, and induces Apoptosis response through Bax
translocation from cytosol to mitochondria.


In mice bearing HCT116 xenografts, MG-101 (10 mg/kg i.p.) inhibits colon tumor formation.

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Product Categories : Proteases > Cysteine Protease Inhibitor