357.41 E-64 is an irreversible and selective Cysteine Protease Inhibitor with IC50 of 9 nM for papain.
E-64 rapidly inhibits the activities of the cysteine proteinases
cathepsins B, H and L and papain, while has no effect on the serine
proteinases or the metalloproteinases. E-64, as a specific inhibitor os cysteine Proteases, effectively blocks in vitro ovarian cancer cell invasion.
In addition, E-64 also shows antiparasitic activity against Giardia lamblia excystation in vitro. E-64 improves the preimplantation development of bovine somatic cell
nuclear transfer embryos, which indicates another important implication
E-64 induces a marked decrease in the number of spontaneous metastasis
in M5076 tumor bearing mice, while has no effect on the formation of
experimental metastasis. E-64 also shows antiparasitic activity against Giardia lamblia excystation in infected mice.
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