Mycophenolate Mofetil 128794-94-5

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Molecular Weight:

433.49 Mycophenolate Mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.






Biological Activity


Mycophenolate mofetil is an ester prodrug of the active
immunosuppressant mycophenolic acid (MPA). The latter shows a
noncompetitive, selective and reversible inhibition activity against
inosine monophosphate dehydrogenase type I/II with IC50 of 39 nM and 27
nM, respectively. Moreover, MPA also produces the
concentration-dependent inhibition of proliferation of ConA-stimulated T
cells, LPS-stimulated B cells and alloantigen-specific T cells with
IC50 of 100 nM, 120 nM, and 51 nM, respectively.


Mycophenolate mofetil with high concentration of 10 μg/mL induces a
strong Apoptosis in microglial cell cultures and increases the number of
activated caspase-3 immunoreactive apoptotic cells. In addition,
Mycophenolate mofetil (1 μg/mL) strongly inhibits proliferation of both
microglial cells and astrocytes. A recent study shows
that Mycophenolate mofetil significantly attenuates the extent of
neuronal cell death of organotypic hippocampal slice cultures after
neuronal injury in a time-dependent manner.


In an ACI-to-Lewis rat heterotopic cardiac transplant model, treatment
of Mycophenolate mofetil at doses of 20 mg/kg and 40 mg/kg leads to a
prolongation of graft survival, with median survival time (MST) of 14.5
days and 18.5 days, respectively. In bleomycin
(BLM)-induced scleroderma mouse model, Mycophenolate mofetil reduces
inflammatory-cell infiltration, tissue hydroxyproline content and dermal
thickness.

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Product Categories : Metabolism > Dehydrogenase Inhibitor