Find Pyruvate Dehydrogenase Inhibitor, Pyrimidine Synthesis Inhibitor, Liver-Targeting Inhibitor on Industry Directory, Reliable Manufacturer/Supplier/Factory from China.

Inquiry Basket (0)
Home > Products > Metabolism > Dehydrogenase Inhibitor > Leflunomide 75706-12-6

Leflunomide 75706-12-6

Product Description

.cp_wz table {border-top: 1px solid #ccc;border-left:1px solid #ccc; } .cp_wz table td{border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc;border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;}


Molecular Weight:

270.21 Leflunomide is a Pyrimidine Synthesis Inhibitor belonging to the DMARD, used as an immunosuppressant agent.






Biological Activity


Leflunomide is actually a prodrug that is processed in vivo to the
active metabolite A771726,which has been shown to inhibit proliferation
of mononuclear and T-cells. Leflunomide is an inhibitor of several
protein tyrosine kinases, with IC50 values between 30 mM and 100 mM in
vitro cellular and enzymatic assays. Leflunomide is
capable of inhibiting anti-CD3- and interleukin-2 (IL-2)-stimulated T
cell proliferation.


Leflunomide is able to inhibit p59fyn and p56lck
activity in in vitro tyrosine kinase assays. Leflunomide also inhibits
Ca2+ mobilization in Jurkat cells stimulated by anti-CD3 antibody but
not in those stimulated by ionomycin. Leflunomide also inhibits distal
events of anti-CD3 monoclonal antibody stimulation, namely, IL-2
production and IL-2 receptor expression on human T lymphocytes.


Leflunomide also inhibits tyrosine phosphorylation in CTLL-4 cells
stimulated by IL-2. Leflunomide is an immunomodulatory
drug that may exert its effects by inhibiting the mitochondrial enzyme
dihydroorotate dehydrogenase (DHODH), which plays a key role in the de
novo synthesis of the pyrimidine ribonucleotide uridine monophosphate
(rUMP). Leflunomide prevents the expansion of activated and autoimmune
lymphocytes by interfering with the Cell Cycle progression due to
inadequate production of rUMP and utilizing mechanisms involving p53.


Leflunomide is able to prevent and reverse allograft and xenograft rejection in rodents, dogs, and monkeys.

Contact us if you need more details on 75706-12-6. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Leflunomide 75706-12-6、75706-12-6 Leflunomide. If these products fail to match your need, please contact us and we would like to provide relevant information.

Product Categories : Metabolism > Dehydrogenase Inhibitor