Pemetrexed 150399-23-8

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Molecular Weight:

471.37 Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.






Biological Activity


Pemetrexed
disodium shows the antiproliferative activity in CCRF-CEM leukemia,
GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells with IC50 of
25 nM, 34 nM and 220 nM, respectively.


A recent study
shows that cisplatin plus Pemetrexed combined with SOCS-1 gene delivery
shows the antitumor effect by inhibition of cell proliferation,
invasiveness, and induction of Apoptosis in MPM cells infected with
adenovirus-expressing SOCS-1 vector.


In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed
disodium produces a duration-dependent tumor growth delay (TGD).

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