Pemetrexed 150399-23-8
Product Description
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Molecular Weight:
471.37 Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
Biological Activity
Pemetrexed disodium shows the antiproliferative activity in CCRF-CEM
leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells
with IC50 of 25 nM, 34 nM and 220 nM, respectively. A
recent study shows that cisplatin plus Pemetrexed combined with SOCS-1
gene delivery shows the antitumor effect by inhibition of cell
proliferation, invasiveness, and induction of Apoptosis in MPM cells
infected with adenovirus-expressing SOCS-1 vector.
In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed
disodium produces a duration-dependent tumor growth delay (TGD).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Contact us if you need more details on 150399-23-8. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Pemetrexed 150399-23-8、150399-23-8 Pemetrexed. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight:
471.37 Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
Biological Activity
Pemetrexed disodium shows the antiproliferative activity in CCRF-CEM
leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells
with IC50 of 25 nM, 34 nM and 220 nM, respectively. A
recent study shows that cisplatin plus Pemetrexed combined with SOCS-1
gene delivery shows the antitumor effect by inhibition of cell
proliferation, invasiveness, and induction of Apoptosis in MPM cells
infected with adenovirus-expressing SOCS-1 vector.
In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed
disodium produces a duration-dependent tumor growth delay (TGD).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Contact us if you need more details on 150399-23-8. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Pemetrexed 150399-23-8、150399-23-8 Pemetrexed. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Metabolism > DHFR Inhibitor
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