Mechlorethamine HCl 55-86-7
Product Description
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Molecular Weight:
192.51 Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
Biological Activity
Mechlorethamine
is much less toxic to rat hepatocytes under nitrogen and causes much
less lipid peroxidation than under aerobic conditions. Mechlorethamine markedly inhibits cell growth and leads to cell
detachment associated with rearrangement of the cytoskeletal Proteins in
rabbit tracheal primary cultures.
Mechlorethamine results in early
lipid peroxidation and cellular membrane damage in rabbit tracheal
primary cultures, this is correlated with a significant increase in the
activities of antioxidant enzymes associated with an increase in
glutathione content.
Mechlorethamine (1.5 mg/kg i.v.) reduces mean leukocyte count from 6,320 mm3 to 1,890 mm3 without any change in the leukocyte differential or erythrocyte and platelet counts in rabbits.
Mechlorethamine (0.005 mg-0.5 mg, i.d.) causes dose-dependent skin
ulcers in the mouse, and isotonic sodium thiosulfate (0.167 M) or
hypertonic (0.34 M) (0.05 mL) given immediately after Mechlorethamine
significantly reduces the mean HN2 ulceration area and the total time of
ulceration.
Contact us if you need more details on 55-86-7. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Mechlorethamine HCl 55-86-7、55-86-7 Mechlorethamine HCl. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight:
192.51 Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
Biological Activity
Mechlorethamine
is much less toxic to rat hepatocytes under nitrogen and causes much
less lipid peroxidation than under aerobic conditions. Mechlorethamine markedly inhibits cell growth and leads to cell
detachment associated with rearrangement of the cytoskeletal Proteins in
rabbit tracheal primary cultures.
Mechlorethamine results in early
lipid peroxidation and cellular membrane damage in rabbit tracheal
primary cultures, this is correlated with a significant increase in the
activities of antioxidant enzymes associated with an increase in
glutathione content.
Mechlorethamine (1.5 mg/kg i.v.) reduces mean leukocyte count from 6,320 mm3 to 1,890 mm3 without any change in the leukocyte differential or erythrocyte and platelet counts in rabbits.
Mechlorethamine (0.005 mg-0.5 mg, i.d.) causes dose-dependent skin
ulcers in the mouse, and isotonic sodium thiosulfate (0.167 M) or
hypertonic (0.34 M) (0.05 mL) given immediately after Mechlorethamine
significantly reduces the mean HN2 ulceration area and the total time of
ulceration.
Contact us if you need more details on 55-86-7. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Mechlorethamine HCl 55-86-7、55-86-7 Mechlorethamine HCl. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : DNA Damage > DNA/RNA Synthesis Inhibitor
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