Chlorpromazine HCl 69-09-0

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Molecular Weight: 355.33 Chlorpromazine HCl is a dopamine and Potassium Channel Inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents

Chlorpromazine affects miniature IPSCs (mIPSCs) by decreasing the
binding (kon) and by increasing the unbinding (koff) rates of GABAARs. Chlorpromazine modulates activated TRPA1 currents in a
voltage-dependent way, leading to a block at positive potentials and an
increased open probability at negative potentials.

Chlorpromazine independently down-regulates the production of various T
cell-derived lymphokines (IL-2, IFN-gamma, IL-4, TNF, and GM-CSF) and
up-regulates the secretion of IL-10 in an in vivo model of acute
superantigen-driven immune activation. Chlorpromazine -mediated
amplification of the SEB-driven Chlorpromazine secretion is accompanied
by an enhanced IL-10 mRNA accumulation. Chlorpromazine
protects mice, normal or adrenalectomized, and guinea pigs against
lethality of LPS, and inhibits TNF serum levels.


Chlorpromazine protects
against LPS lethality when administered 30 minutes (min) before,
simultaneously, or up to 10 min after LPS and is ineffective when given
30 min after LPS, paralleling the inhibitory effect on TNF production.
Chlorpromazine significantly inhibits LPS lethality and hepatotoxicity
in mice sensitized to LPS toxicity by actinomycin D, whereas under these
conditions DEX is inactive. Chlorpromazine protects
brain tissue from hypoxia-induced irreversible loss of synaptic
transmission in rats. Chlorpromazine also significantly delays the
occurrence of the hypoxia-induced spreading depression (SD) in rats.



Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	355.33
Formula	C17H19ClN2S.HCl
CAS No.	69-09-0

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Sonazine

Solubility (25°C) *	In vitro	DMSO	71 mg/mL (199.81 mM)
		Water	71 mg/mL (199.81 mM)
		Ethanol	71 mg/mL (199.81 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine,hydrochloride (1:1)

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