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Penfluridol 26864-56-2

Product Description

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Molecular Weight: 523.97 Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

Penfluridol is a neuroleptic drug with long duration of action, which is
able to relieve both negative and positive symptoms of schizophrenia.
Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the
dopamine projections in the limbic system and in mesocortical area.






Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)










Chemical Information




Molecular Weight (MW) 523.97
Formula

C28H27ClF5NO

CAS No. 26864-56-2

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms



Solubility (25°C) * In vitro DMSO 100 mg/mL (190.85 mM)
Water <1 mg/mL (
Ethanol 100 mg/mL (190.85 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.




Chemical Name 4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-







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