Penfluridol 26864-56-2
Product Description
.cp_wz table {border-top: 1px solid #ccc;border-left:1px solid #ccc; } .cp_wz table td{border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc;border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;}
Molecular Weight: 523.97 Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Penfluridol is a neuroleptic drug with long duration of action, which is
able to relieve both negative and positive symptoms of schizophrenia.
Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the
dopamine projections in the limbic system and in mesocortical area.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
Molarity Calculator
Dilution Calculator
Molecular Weight Calculator
Contact us if you need more details on 26864-56-2. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 26864-56-2 Penfluridol、Penfluridol 26864-56-2. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight: 523.97 Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Penfluridol is a neuroleptic drug with long duration of action, which is
able to relieve both negative and positive symptoms of schizophrenia.
Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the
dopamine projections in the limbic system and in mesocortical area.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Chemical Information
Molecular Weight (MW) | 523.97 |
---|---|
Formula | C28H27ClF5NO |
CAS No. | 26864-56-2 |
Storage | 3 years -20℃Powder |
---|---|
6 months-80℃in solvent (DMSO, water, etc.) | |
Synonyms | |
Solubility (25°C) * | In vitro | DMSO | 100 mg/mL (190.85 mM) |
---|---|---|---|
Water | <1 mg/mL ( | ||
Ethanol | 100 mg/mL (190.85 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Chemical Name | 4-Piperidinol, 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]- |
---|
Molarity Calculator
Dilution Calculator
Molecular Weight Calculator
Contact us if you need more details on 26864-56-2. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 26864-56-2 Penfluridol、Penfluridol 26864-56-2. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Neuronal Signaling > Dopamine Receptor Inhibitor
Other Products
Hot Products
Astragaloside AChlortetracycline HCl 64-72-2Paclitaxel 33069-62-4Dexamethasone Acetate 1177-87-3Dinaciclib (SCH727965) 779353-01-4CHIR-124 405168-58-3Ro3280 1062243-51-9TAME 901-47-3CCG-1423 285986-88-110058-F4 403811-55-2Dabigatran (BIBR 953) 211914-51-1H 89 2HCl 130964-39-5T0901317 293754-55-9Aprepitant 170729-80-3Turofexorate Isopropyl (XL335) 629664-81-9BMS-378806 357263-13-9