Pergolide Mesylate 66104-23-2

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Pergolide mesylate (trade name Permax) is an ergoline-based dopamine
receptor agonist used in some countries for the treatment of Parkinson's
disease. Pergolide mesylate functions as an agonist at the dopamine D2,
D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline.




Pergolide mesylate decreases plasma prolactin concentrations. The weak agonist activity of pergolide at D1 receptors somewhat alters
its clinical and side effect profile in the treatment of Parkinson's
disease. The drug is in decreasing use, as it is reported to be
associated with a form of heart disease called cardiac fibrosis. The
use of pergolide or cabergoline is associated with a significantly
increased risk of newly diagnosed cardiac-valve regurgitation.





Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	410.59
Formula	C19H26N2S.CH4O3S
CAS No.	66104-23-2

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	LY127809

Solubility (25°C) *	In vitro	DMSO	10 mg/mL (24.35 mM)
		Water	82 mg/mL (199.71 mM)
		Ethanol	<1 mg/mL (
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	Ergoline, 8-[(methylthio)methyl]-6-propyl-, (8β)-, monomethanesulfonate (9CI)

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Product Categories : Neuronal Signaling > Dopamine Receptor Inhibitor