(-)-Parthenolide 20554-84-1

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Molecular Weight: 248.32 (-)-Parthenolide is a sesquiterpene lactone which occurs naturally in the plant feverfew(Tanacetum parthenium) and also promotes the ubiquitination of MDM2 and activates p53 cellular functions.

Biological Activity

Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Parthenolide ((-)-Parthenolide) has several biological activities. Parthenolide is active against a parasite Leishmania amazonensis. Parthenolide ((-)-Parthenolide) is also a potential anticancer agent. Parthenolide ((-)-Parthenolide) destroys acute myelogenous leukemia (AML) cells by inducing Apoptosis. Parthenolide ((-)-Parthenolide) also has anti-inflammatory and anti-hyperalgesic effects.






Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	248.32
Formula	C15H20O3
CAS No.	20554-84-1

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	50 mg/mL (201.35 mM)
		Water	<1 mg/mL (
		Ethanol	50 mg/mL (201.35 mM)
	In vivo	30% PEG400/0.5% Tween80/5% propylene glycol	30 mg/mL

Chemical Name	Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bR)-

Stock Solution (1ml DMSO)	1mM	10mM	20mM	30mM
Mass(mg)	0.24832	2.4832	4.9664	7.4496

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