Chrysophanic Acid 481-74-3

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Molecular Weight:

254.24 Chrysophanic acid (Chrysophanol), a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.


Biological Activity


Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor.
Chrysophanic acid (Chrysophanol) is a natural anthraquinone, has
anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer
cells. Chrysophanic acid (Chrysophanol) preferentially blocks
proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29,
KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression.


Chrysophanic acid (Chrysophanol) treatment in SNU-C5 cells inhibits
EGF-induced phosphorylation of EGFR and suppresses activation of
downstream signaling molecules, such as AKT, extracellular
signal-regulated kinase (ERK) and the mammalian target of rapamycin
(mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic
acid also inhibits the replication of poliovirus types 2 and 3
(Picornaviridae) and poliovirus-induced cytopathic effects in BGM
(Buffalo green monkey) kidney cells.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	254.24
Formula	C15H10O4
CAS No.	481-74-3

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Chrysophanol

Chemical Name	1,8-dihydroxy-3-methylanthracene-9,10-dione

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Product Categories : Protein Tyrosine Kinase > EGFR Inhibitor