Bromosporine 1619994-69-2
Product Description
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Molecular Weight:
404.44 Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.
Biological Activity
In
cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of
BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and
SMARCA2 even at 10 µM. Bromosporine shows moderate cytotoxicity in HeLa
cells at 18 µM. Bromosporine, as a chemical probe for bromodomain
functional assays, will be very useful in elucidating further biological
roles of reader domains.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
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Contact us if you need more details on 1619994-69-2. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Bromosporine 1619994-69-2、1619994-69-2 Bromosporine. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight:
404.44 Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.
Biological Activity
In
cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of
BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and
SMARCA2 even at 10 µM. Bromosporine shows moderate cytotoxicity in HeLa
cells at 18 µM. Bromosporine, as a chemical probe for bromodomain
functional assays, will be very useful in elucidating further biological
roles of reader domains.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Chemical Information
Molecular Weight (MW) | 404.44 |
---|---|
Formula | C17H20N6O4S |
CAS No. | 1619994-69-2 |
Storage | 3 years -20℃Powder |
---|---|
6 months-80℃in solvent (DMSO, water, etc.) | |
Synonyms | |
Solubility (25°C) * | In vitro | DMSO | 81 mg/mL (200.27 mM) |
---|---|---|---|
Water | <1 mg/mL ( | ||
Ethanol | <1 mg/mL ( | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Chemical Name | ethyl 3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbamate |
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Dilution Calculator
Molecular Weight Calculator
Contact us if you need more details on 1619994-69-2. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Bromosporine 1619994-69-2、1619994-69-2 Bromosporine. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Epigenetics > Epigenetic Reader Domain Inhibitor
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