Biochanin A 491-80-5

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Molecular Weight:

284.26 Biochanin A, an O-methylated isoflavone from Trifolium pratense, inhibits Protein Tyrosine Kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.






Biological Activity


Biochanin A has been reported to inhibit protein tyrosine kinase (PTK)
of epidermal growth factor receptor with IC50 values of 91.5 μM Biochanin A inhibits the hydrolysis of 0.5 μM anandamide by mouse, rat
and human fatty acid amide hydrolase (FAAH) with IC50 values of 1.8, 1.4
and 2.4 μM respectively.


Biochanin A inhibits both serum
and EGF-stimulated growth of LNCaP and DU-145 cells (IC50 values from
8.0 to 27 micrograms/ml for serum and 4.3 to 15 micrograms/ml for EGF),
but has no significant effect of the EGF receptor tyrosine
autophosphorylation.


LD50: Mice 63mg/kg (i.p.)






Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

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