NMDA (N-Methyl-D-aspartic acid) 6384-92-5

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Molecular Weight: 147.13 NMDA(N-Methyl-D-aspartic acid)is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4.

Biological Activity
NMDA is an excitatory amino acid neurotransmitter, which only binds to
the NMDA receptor without effecting other glutamate receptors (such as
those for AMPA and kainate). NMDA specifically binds to the NR2 subunits
of NMDA receptor, and then stimulates the open of non-specific cation
channel which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. Activation of the NMDA receptor is able to produce the
excitatory postsynaptic potential (EPSP), and trigger the increase of
intracellular Ca2+ content which may further take
participating in various signaling pathways. NMDA receptor plays a key
role in a wide range of physiological (e.g. long-term potentiation and
neuronal plasticity) and pathological processes (e.g. excitotoxicity and
epilepsy).




Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

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