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Bikinin 188011-69-0

Product Description

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Molecular Weight: 273.08 Bikinin is an ATP-competitive Arabidopsis GSK-3 Inhibitor, and acts as a strong activator of brassinosteroid (BR) signaling.


Bikinin directly targets BIN2 of Arabidopsis GSK-3s and activates brassinosteroid-dependent gene expression. Bikinin also inhibits RD26 expression, and inhibits the induction of GUS activity by 150 mM NaCl in the RD26pro:GUS line.Bikinin strongly inhibits abscisic acid signaling outputs, and inhibits
T180 phosphorylation of SnRK2.3 and its kinase activity in vivo.









Kinase Assays The BIN2 kinase assay with GST-BIN2 and maltose binding protein (MaBP) fused to BES1 (MaBP-BES1) as a substrate is done as reported elsewhere. Kinase assays of the ASKs, AtMPK4 and AtMPK6 with myelin basic protein (MBP), AURORA1 with histone H3, and of the human kinases. Comparable activities of the different ASKs are used. For one particular kinase equal amounts (ranging from 20 to 100 ng depending on the innate kinase activity) are used in the assays with and without bikinin.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)






Chemical Information




Molecular Weight (MW) 273.08
Formula

C9H9BrN2O3

CAS No. 188011-69-0

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms N/A






Chemical Name 4-(5-bromopyridin-2-ylamino)-4-oxobutanoic acid







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