Purmorphamine 483367-10-8

.cp_wz table {border-top: 1px solid #ccc;border-left:1px solid #ccc; } .cp_wz table td{border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc;border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;}


Molecular Weight: 520.62 Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.

Biological Activity

Purmorphamine activates the Hedgehog pathway by directly binds and
activates Smoothened with IC50 of ~ 1.5 μM in compete with cyclopamine, a
Smo antagonist. Purmorphamine is a potent inducer of
osteogenesis in multipotent C3H10T1/2 cells.


The EC50 (based on ALP
expression) for Purmorphamine is 1 μM in C3H10T1/2 cells. Purmorphamine
(1 μM) and BMP-4 (100 ng/mL) together increase ALP activity more than
90-fold in 3T3-L1 cells. In contrast to BMP-4,
Purmorphamine induces osteogenesis by activating Hedgehog signaling in
multipotent mesenchymal progenitor cells.


Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats.

Contact us if you need more details on 483367-10-8. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Purmorphamine 483367-10-8、483367-10-8 Purmorphamine. If these products fail to match your need, please contact us and we would like to provide relevant information.

Product Categories : Stem Cells & Wnt > Hedgehog/Smoothened Inhibitor