L idocaine 137-58-6

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Lid ocaine Chemical Structure

Molecular Weight: 234.34 Li docaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Biological Activity

Li docaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Histamine is responsible for many features of allergic reactions. Lid ocaine (Alphacaine)is a second-generation antihistamine agent closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine, used to treat allergies.






Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	234.34
Formula	C14H22N2O
CAS No.	137-58-6

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Alphacaine

Solubility (25°C) *	In vitro	DMSO	47 mg/mL (200.56 mM)
		Water	9 mg/mL (38.4 mM)
		Ethanol	47 mg/mL (200.56 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	2-(diethylamino)-N-(2,6-dimethylphenyl)-acetamide

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Product Categories : Neuronal Signaling > Histamine Receptor Inhibitor