Li docaine 137-58-6
Product Description
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Molecular Weight: 234.34 L idocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Biological Activity
Lid ocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Histamine is responsible for many features of allergic reactions. Li docaine (Alphacaine)is a second-generation antihistamine agent closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine, used to treat allergies.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
Contact us if you need more details on 137-58-6 Li Docaine. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Li Docaine 137-58-6、137-58-6. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight: 234.34 L idocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Biological Activity
Lid ocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Histamine is responsible for many features of allergic reactions. Li docaine (Alphacaine)is a second-generation antihistamine agent closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine, used to treat allergies.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Chemical Information
Molecular Weight (MW) | 234.34 |
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Formula | C14H22N2O |
CAS No. | 137-58-6 |
Storage | 3 years -20℃Powder |
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6 months-80℃in solvent (DMSO, water, etc.) | |
Synonyms | Alphacaine |
Solubility (25°C) * | In vitro | DMSO | 47 mg/mL (200.56 mM) |
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Water | 9 mg/mL (38.4 mM) | ||
Ethanol | 47 mg/mL (200.56 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Chemical Name | 2-(diethylamino)-N-(2,6-dimethylphenyl)-acetamide |
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Contact us if you need more details on 137-58-6 Li Docaine. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Li Docaine 137-58-6、137-58-6. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Neuronal Signaling > Histamine Receptor Inhibitor
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