Pravastatin sodium 81131-70-6
Product Description
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Molecular Weight:
446.51 Pravastatin sodium is an HMG-CoA Reductase Inhibitor against sterol synthesis with IC50 of 5.6 μM.
Biological Activity
Pravastatin-Na at 10 μM inhibits the sterol synthesis at a level greater than 50% in PBMC. Pravastatin produces relaxation of isolated aortic rings, with maximum
vasorelaxations of 62.8% at 10 μM and latency of ~8 min. Pravastatin
( Pravastatin results in a dose-dependent inhibition of macrophage
cholesterol synthesis in human monocyte derived macrophages(HMDM), mouse
peritoneal macrophages (MPM) and a J-774 A.1 macrophagelike cell lines.
Small concentrations of pravastatin
Pravastatin (40 mg, single dose) causes a reduction in cholesterol
synthesis in human monocyte derived macrophages by 62% in healthy
subjects and 47% in hypercholesterolaemic patients. Pravastatin (40
mg/day, 8 weeks) results in a 55% inhibition of cholesterol synthesis
and a 57% increase in LDL degradation in hypercholesterolaemic patients.
Pravastatin (30 mg/kg/d) results in decreased length of
the dystrophic lesions by 34% and recovery of muscular structure in Male
Wistar rats receiving irradiation, associated with decreased CCN2
level.
Contact us if you need more details on 81131-70-6. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Pravastatin Sodium 81131-70-6、81131-70-6 Pravastatin Sodium. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight:
446.51 Pravastatin sodium is an HMG-CoA Reductase Inhibitor against sterol synthesis with IC50 of 5.6 μM.
Biological Activity
Pravastatin-Na at 10 μM inhibits the sterol synthesis at a level greater than 50% in PBMC. Pravastatin produces relaxation of isolated aortic rings, with maximum
vasorelaxations of 62.8% at 10 μM and latency of ~8 min. Pravastatin
( Pravastatin results in a dose-dependent inhibition of macrophage
cholesterol synthesis in human monocyte derived macrophages(HMDM), mouse
peritoneal macrophages (MPM) and a J-774 A.1 macrophagelike cell lines.
Small concentrations of pravastatin
Pravastatin (40 mg, single dose) causes a reduction in cholesterol
synthesis in human monocyte derived macrophages by 62% in healthy
subjects and 47% in hypercholesterolaemic patients. Pravastatin (40
mg/day, 8 weeks) results in a 55% inhibition of cholesterol synthesis
and a 57% increase in LDL degradation in hypercholesterolaemic patients.
Pravastatin (30 mg/kg/d) results in decreased length of
the dystrophic lesions by 34% and recovery of muscular structure in Male
Wistar rats receiving irradiation, associated with decreased CCN2
level.
Contact us if you need more details on 81131-70-6. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Pravastatin Sodium 81131-70-6、81131-70-6 Pravastatin Sodium. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Metabolism > HMG-CoA Reductase Inhibitor
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