Fluvastatin Sodium 93957-55-2

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Molecular Weight:

433.45 Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM.






Biological Activity


Fluvastatin markedly inhibits the formation of thiobarbituric acid
reactive substances in iron (II)-supported peroxidation of liposomes
with IC50 of 12 μM. Fluvastatin ranging from 1 μM to 100 μM inhibits
peroxyl radical-mediated peroxidation of liposomes induced by
water-soluble and lipid-soluble radical generators, 2,2'-azobis
(2-amidinopropane) dihydro-chloride and 2,2'-azobis
(2,4-dimethylvaleronitrile), respectively.


Fluvastatin (4
mM) and its metabolites shows superoxide anion scavenging activity in
the hypoxanthine-xanthine oxidase system and a strong scavenging effect
on the hydroxyl radical produced from Fenton's reaction. Fluvastatin (8
μM) and its metabolites shows protective effects on DNA Damage as potent
as the reference Antioxidants, ascorbic acid, trolox, and probucol in
CHL/IU cells. Fluvastatin (100 nM) shows a dose-dependent
decrease in Ang II-activated superoxide anion formation in human aortic
smooth muscle cells (hASMC).


Fluvastatin (10 mg/kg/day) results in a decrease in serum lipids in
rabbits feed a 1.5% cholesterol containing diet. Fluvastatin (10
mg/kg/day) significantly lowers the tissue ACE in the aortae in rabbits
feed a 1.5% cholesterol containing diet. Fluvastatin (10 mg/kg/day)
significantly reverses the suppression of ACh-induced relaxation in
rabbits feed a 1.5% cholesterol containing diet.

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Product Categories : Metabolism > HMG-CoA Reductase Inhibitor