Isotretinoin 4759-48-2
Product Description
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Molecular Weight:
300.44 It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Biological Activity
Isotretinoin is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. It is still used in the treatment of these cancers to this day because of its ability to kill rapidly dividing cells.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
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Contact us if you need more details on 4759-48-2. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Isotretinoin 4759-48-2、4759-48-2 Isotretinoin. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight:
300.44 It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Biological Activity
Isotretinoin is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. It is still used in the treatment of these cancers to this day because of its ability to kill rapidly dividing cells.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Chemical Information
Molecular Weight (MW) | 300.44 |
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Formula | C20H28O2 |
CAS No. | 4759-48-2 |
Storage | 3 years -20℃Powder |
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6 months-80℃in solvent (DMSO, water, etc.) | |
Synonyms | 13-cis retinoic acid |
Solubility (25°C) * | In vitro | DMSO | 60 mg/mL (199.7 mM) |
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Water | <1 mg/mL ( | ||
Ethanol | 8 mg/mL (26.62 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Chemical Name | (2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid |
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Molarity Calculator
Dilution Calculator
Molecular Weight Calculator
Contact us if you need more details on 4759-48-2. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Isotretinoin 4759-48-2、4759-48-2 Isotretinoin. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Metabolism > Hydroxylase Inhibitor
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