Nobiletin 478-01-3

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Molecular Weight:

402.39 Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities.






Biological Activity


Nobiletin, a citrus flavonoid isolated from citrus peels like in
tangerine, which has anti-inflammatory and anti-tumor activities.
Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both
NO and O 2- generation. Nobiletin significantly inhibites
two skin inflammation induced by double TPA application. It also
suppresses the expression of cyclooxygenase-2 and inducible NO synthase
Proteins and prostaglandin E2 release.


Nobiletin
inhibites the tumor-invasive activity of human fibrosarcoma HT-1080
cells in the Matrigel model, not only by suppressing the expression of
MMPs but also augmenting TIMP-1 production through interfering the
phosphatidylinositol 3-kinase pathway (PI3-K). Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation.

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Product Categories : Proteases > MMP Inhibitor