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Home > Products > Proteases > MMP Inhibitor > Doxycycline HCl 10592-13-9

Doxycycline HCl 10592-13-9

Product Description

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Molecular Weight:

480.9 Doxycycline HCl is a tetracycline antibiotic that commonly used to treat a variety of infections and MMP Inhibitor.






Biological Activity


Doxycycline (50 μM) completely inhibits degradation of type II collagen,
but not that of type I collagen in rheumatoid synovial fibroblasts and
endothelial cells. Doxycycline (50 μM) down-regulated MMP-8 induction,
at both the mRNA and protein levels in rheumatoid synovial fibroblasts
and endothelial cells. Doxycycline not only inhibits
MMP-8 and MMP-9 (gelatinase B) activity, but also the synthesis of MMPs
in human endothelial cells.


Doxycycline (50 μM) completely inhibits the
phorbol-12-myristate-13-acetate (PMA)-mediated induction of MMP-8 and
MMP-9, as measured by Western blotting and gelatin zymography,
respectively. Doxycycline inhibits the LPS-induced
IL-1beta increase in the mRNA and protein amounts in the corneal
epithelium and upregulates the expression of the anti-inflammatory IL-1
RA protein in human cultured corneal epithelium.


Doxycycline reduces the
steady state level of the cellular ICE protein but does not affect the
level of ICE transcripts. Doxycycline significantly decreases IL-1beta
bioactivity in the supernatants from LPS-treated corneal epithelial
cultures.


Doxycycline (25 mg/day) prevents the structural deterioration of aortic
elastin without decreasing the influx of inflammatory cells in Wistar
rats. Doxycycline (25 mg/day) markedly suppresses increased aortic wall
production of 92 kD gelatinase in Wistar rats. Doxycycline reduces the activity of matrix metalloproteinase (MMP)-2 and
MMP-9 in the arterial wall, and inhibits smooth muscle cell migration
from media to intima by 77% at 4 days after balloon injury in rats.
Doxycycline reduces the replication of smooth muscle cells in the intima
in rats.

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Product Categories : Proteases > MMP Inhibitor