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Inosine 58-63-9

Product Description

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Molecular Weight: 268.23 Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring via a β-N9-glycosidic bond.


Biological Activity


Inosine is a nucleoside that is formed when hypoxanthine is attached to a
ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.
Inosine is commonly found in tRNAs and is essential for proper
translation of the genetic code in wobble base pairs. Knowledge of
inosine Metabolism has led to advances in immunotherapy in recent
decades. Inosine monophosphate is oxidised by the enzyme inosine
monophosphate dehydrogenase, yielding xanthosine monophosphate, a key
precursor in purine metabolism.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)










Chemical Information




Molecular Weight (MW) 268.23
Formula

C10H12N4O5

CAS No. 58-63-9

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms






Chemical Name 1,9-Dihydro-9-β-D-ribofuranosyl-6H-purin-6-one; 6H-Purin-6-one, 1,9-dihydro-9-β-D-ribofuranosyl-






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