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Hypoxanthine 68-94-0

Product Description

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Molecular Weight: 136.11 Hypoxanthine is a naturally occurring purine derivative.


Biological Activity


Hypoxanthine is a naturally occurring purine derivative. It is
occasionally found as a constituent of nucleic acids, where it is
present in the anticodon of tRNA in the form of its nucleoside inosine.
It has a tautomer known as 6-hydroxypurine. Hypoxanthine is a necessary
additive in certain cell, bacteria, and parasite cultures as a substrate
and nitrogen source.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)








Chemical Information




Molecular Weight (MW) 136.11
Formula

C5H4N4O

CAS No. 68-94-0

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms



Solubility (25°C) * In vitro DMSO 0.4 mg/mL (2.93 mM)
Water <1 mg/mL (
Ethanol <1 mg/mL (
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.




Chemical Name 6H-Purin-6-one, 1,9-dihydro-







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