.cp_wz table {border-top: 1px solid #ccc;border-left:1px solid #ccc; } .cp_wz table td{border-right: 1px solid #ccc; border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;} .cp_wz table th {border-right: 1px solid #ccc;border-bottom: 1px solid #ccc; padding: 5px 0px 0px 5px;}
Molecular Weight: 136.11 Allopurinol is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
Biological Activity
Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 µM.
Xanthine oxidase is responsible for the successive oxidation of hypoxanthine and xanthine resulting in the production of uric acid, the product of human purine
Metabolism. The inhibition of XO activity by 6-aminopurine (IC50=10.89±0.13 µM) and its analogues was compared with that by allopurinol (IC50=7.82±0.12 µM). Among these analogues, 2-chloro-6(methylamino)purine (IC50=10.19±0.10 µM) and 4-aminopyrazolo[3,4-d] pyrimidine (IC50=30.26±0.23 µM) were found to be potent
Inhibitors of XO.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
| Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
| Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
| Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
| Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
| rat Km(6) |
Chemical Information
| Molecular Weight (MW) | 136.11 |
| Formula | C5H4N4O |
| CAS No. | 315-30-0 |
| Storage | 3 years -20℃Powder |
| 6 months-80℃in solvent (DMSO, water, etc.) |
| Synonyms |
|
| Solubility (25°C) * | In vitro | DMSO | 27 mg/mL (198.36 mM) |
| Water | 4 mg/mL (29.38 mM) |
| Ethanol | 3 mg/mL (22.04 mM) |
| |
| Chemical Name | 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one |
Contact us if you need more details on Allopurinol. We are ready to answer your questions on packaging, logistics, certification or any
other aspects about 315-30-0 Allopurinol、315-30-0. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Others > Other
