Zonisamide 68291-97-4
Product Description
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Molecular Weight: 212.23 Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive.
Biological Activity
Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
Contact us if you need more details on Zonisamide. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 68291-97-4 Zonisamide、68291-97-4. If these products fail to match your need, please contact us and we would like to provide relevant information.
Molecular Weight: 212.23 Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive.
Biological Activity
Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
| Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
| Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
| Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
| Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
| rat Km(6) |
Chemical Information
| Molecular Weight (MW) | 212.23 |
|---|---|
| Formula | C8H8N2O3S |
| CAS No. | 68291-97-4 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in solvent (DMSO, water, etc.) | |
| Synonyms | CI-912 |
| Solubility (25°C) * | In vitro | DMSO | 42 mg/mL (197.89 mM) |
|---|---|---|---|
| Water | <1 mg/mL ( | ||
| Ethanol | 5 mg/mL (23.55 mM) | ||
| Chemical Name | benzo[d]isoxazol-3-ylmethanesulfonamide |
|---|
Contact us if you need more details on Zonisamide. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 68291-97-4 Zonisamide、68291-97-4. If these products fail to match your need, please contact us and we would like to provide relevant information.
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