D-Pantothenic acid Chemical Structure
Molecular Weight: 219.23954 D-Pantothenic acid is a water-soluble vitamin and an essential nutrient for many animals.
Pantothenic acid(pantothenate) is a water-soluble vitamin and an essential nutrient for for many animals. Pantothenic acid is used in the synthesis of coenzyme A (CoA). Coenzyme A may act as an acyl group carrier to form acetyl-CoA and other related compounds; this is a way to transport carbon atoms within the cell. CoA is important in energy Metabolism for pyruvate to enter the tricarboxylic acid cycle(TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle. CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
|Body Surface Area (m2)||0.6||0.5||0.24||0.15||0.05||0.025||0.02||0.007|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×||mouse Km(3)||= 11.2 mg/kg|
|Molecular Weight (MW)||219.23954|
|Storage||3 years -20℃Powder|
|6 months-80℃in solvent (DMSO, water, etc.)|
|Synonyms||Pantothenate, Vitamin B5|
|Solubility (25°C) *||In vitro||DMSO||44 mg/mL (200.69 mM)|
|Water||44 mg/mL (200.69 mM)|
|Ethanol||<1 mg/mL (|
|Stock Solution (1ml DMSO)||1mM||10mM||20mM||30mM|
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