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D-Pantothenic acid 79-83-4

Product Description

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D-Pantothenic acid

D-Pantothenic acid Chemical Structure

Molecular Weight: 219.23954 D-Pantothenic acid is a water-soluble vitamin and an essential nutrient for many animals.


Biological Activity


Pantothenic acid(pantothenate) is a water-soluble vitamin and an essential nutrient for for many animals. Pantothenic acid is used in the synthesis of coenzyme A (CoA). Coenzyme A may act as an acyl group carrier to form acetyl-CoA and Other related compounds; this is a way to transport carbon atoms within the cell. CoA is important in energy Metabolism for pyruvate to enter the tricarboxylic acid cycle(TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle. CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)




Chemical Information




Molecular Weight (MW) 219.23954
Formula

C9H17NO5

CAS No. 79-83-4

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms Pantothenate, Vitamin B5



Solubility (25°C) * In vitro DMSO 44 mg/mL (200.69 mM)
Water 44 mg/mL (200.69 mM)
Ethanol <1 mg/mL (





Chemical Name N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-β-alanine







Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.21923954 2.1923954 4.3847908 6.5771862


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