Ivermectin Chemical Structure
Molecular Weight: 875.09 Ivermectin is a broad-spectrum antiparasitic medication.
Ivermectin is a broad-spectrum antiparasitic medication. Ivermectin is used in the treatment of certain worm infections. It is used to treat river blindness(onchocerciasis)and a certain type of diarrhea(strongyloidiasis). Ivermectin appears to work by paralyzing and then killing the offspring of adult worms. It may also slow down the rate at which adult worms reproduce. This results in fewer worms in the skin, blood, and eyes.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
|Body Surface Area (m2)||0.6||0.5||0.24||0.15||0.05||0.025||0.02||0.007|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×||mouse Km(3)||= 11.2 mg/kg|
|Molecular Weight (MW)||875.09|
|Storage||3 years -20℃Powder|
|6 months-80℃in solvent (DMSO, water, etc.)|
|Solubility (25°C) *||In vitro||DMSO||175 mg/mL (199.97 mM)|
|Water||<1 mg/mL (|
|Ethanol||28 mg/mL (31.99 mM)|
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