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Ivermectin 70288-86-7

Product Description

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Ivermectin

Ivermectin Chemical Structure

Molecular Weight: 875.09 Ivermectin is a broad-spectrum antiparasitic medication.


Biological Activity


Ivermectin is a broad-spectrum antiparasitic medication. Ivermectin is used in the treatment of certain worm infections. It is used to treat river blindness(onchocerciasis)and a certain type of diarrhea(strongyloidiasis). Ivermectin appears to work by paralyzing and then killing the offspring of adult worms. It may also slow down the rate at which adult worms reproduce. This results in fewer worms in the skin, blood, and eyes.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)


Species Baboon Dog Monkey Rabbit Guinea pig Rat Hamster Mouse
Weight (kg) 12 10 3 1.8 0.4 0.15 0.08 0.02
Body Surface Area (m2) 0.6 0.5 0.24 0.15 0.05 0.025 0.02 0.007
Km factor 20 20 12 12 8 6 5 3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by Animal B Km
Animal A Km



For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × mouse Km(3) = 11.2 mg/kg
rat Km(6)




Chemical Information







Molecular Weight (MW) 875.09
Formula

C48H74O14

CAS No. 70288-86-7

Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms



Solubility (25°C) * In vitro DMSO 175 mg/mL (199.97 mM)
Water <1 mg/mL (
Ethanol 28 mg/mL (31.99 mM)




Chemical Name no

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