Amiloride HCl 2016-88-8
Product Description
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Amiloride HCl
Amiloride HCl Chemical Structure
Molecular Weight: 266.09 Amiloride HCl, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.
Biological Activity
Amiloride hydrochloride(Midamor), a pyrazine compound inhibit sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Chemical Information
Contact us if you need more details on Amiloride HCl. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 2016-88-8、2016-88-8 Amiloride HCl. If these products fail to match your need, please contact us and we would like to provide relevant information.
Amiloride HCl
Amiloride HCl Chemical Structure
Molecular Weight: 266.09 Amiloride HCl, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.
Biological Activity
Amiloride hydrochloride(Midamor), a pyrazine compound inhibit sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species | Baboon | Dog | Monkey | Rabbit | Guinea pig | Rat | Hamster | Mouse |
Weight (kg) | 12 | 10 | 3 | 1.8 | 0.4 | 0.15 | 0.08 | 0.02 |
Body Surface Area (m2) | 0.6 | 0.5 | 0.24 | 0.15 | 0.05 | 0.025 | 0.02 | 0.007 |
Km factor | 20 | 20 | 12 | 12 | 8 | 6 | 5 | 3 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rat dose (mg/kg) = mouse dose (22.4 mg/kg) × | mouse Km(3) | = 11.2 mg/kg |
rat Km(6) |
Chemical Information
Molecular Weight (MW) | 266.09 |
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Formula | C6H8ClN7O.HCl |
CAS No. | 2016-88-8 |
Storage | 3 years -20℃Powder |
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6 months-80℃in solvent (DMSO, water, etc.) | |
Synonyms | |
Solubility (25°C) * | In vitro | DMSO | 53 mg/mL (199.18 mM) |
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Water | 6 mg/mL (22.54 mM) | ||
Ethanol | 5 mg/mL (18.79 mM) | ||
Chemical Name | 1-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine hydrochloride |
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Contact us if you need more details on Amiloride HCl. We are ready to answer your questions on packaging, logistics, certification or any other aspects about 2016-88-8、2016-88-8 Amiloride HCl. If these products fail to match your need, please contact us and we would like to provide relevant information.
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