Magnolol 528-43-8

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Molecular Weight: 266.33 Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties.


Biological Activity


Magnolol is a bioactive lignin found in the bark of the Houpu magnolia
(Magnolia officinalis) which shows antifungal properties. Magnolol
preferentially increases (3)H-muscimol binding to hippocampus compared
to cortex and cerebellum in vitro. Magnolol has a more potent enhancing
effect on GABAA receptor alpha2 subunit. Magnolol shows
significant inhibitory activities against Trichophyton mentagrophytes,
Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger,
Cryptococcus neoformans, and Candida albicans with minimum inhibitory
concentrations (MIC) in a range of 25-100 μg/ml.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	266.33
Formula	C18H18O2
CAS No.	528-43-8

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	53 mg/mL (199 mM)
		Water	<1 mg/mL (
		Ethanol	53 mg/mL (199 mM)

Chemical Name	[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

Stock Solution (1ml DMSO)	1mM	10mM	20mM	30mM
Mass(mg)	0.26633	2.6633	5.3266	7.9899

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