Indomethacin 53-86-1

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Molecular Weight: 357.79 Indomethacin is a nonselective COX1 and COX2 inhibitor, used to reduce fever, pain, stiffness, and Swelling.


Biological Activity


Indomethacin inhibits transcription of a beta-catenin/TCF-responsive
reporter gene in a dose dependent manner. Indomethacin also
downregulates the beta-catenin/TCF transcriptional target cyclin D1.
Indomethacin attenuates the transcription of beta-catenin/TCF-responsive
genes, by modulating TCF activity without disrupting beta-catenin/TCF
complex formation.






Indomethacin increases BrdU+ cells of all lineages and reduces microglial/monocyte activation in rats after focal cerebral ischemia.
Indomethacin (7.5 mg/kg, one injection) produces acute injury and
inflammation in the distal jejunum and proximal ileum that are maximal
at three days and completely resolves within one week. Indomethacin (two
daily subcutaneous injections) produces a more extensive and chronic
inflammation that lasts in an active form in more than 75% of the rats
for at least two weeks.


Indomethacin (4ppm) reduces tumor yield by 78% in SKH:HR-1-hrBr hairless mice.
Indomethacin (20 mg/kg, orally) increases the total area of gastric
erosions and concentration of lipid peroxides in the gastric mucosa of
rats. Indomethacin increases the alpha-tocopherol:total cholesterol
ratio in serum. Indomethacin inhibits the increases in gastric mucosal
erosions and lipid peroxides in the gastric mucosa, and the reduction of
serum alpha-tocopherol.






Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	357.79
Formula	C19H16ClNO4
CAS No.	53-86-1

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	72 mg/mL (201.23 mM)
		Water	<1 mg/mL (
		Ethanol	24 mg/mL (67.07 mM)

Chemical Name	1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

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