Tanshinone IIA 568-72-9

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Molecular Weight: 294.34 Tanshinone IIA(Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases.


Biological Activity


Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in
Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional
herbal medicine that is used to treat cardiovascular and inflammatory
diseases. Tanshinone IIA protects cardiac myocytes against oxidative
stress-induced Apoptosis. The in vivo protection is mediated by
increased scavenging of oxygen free radicals, prevention of lipid
peroxidation and upregulation of the Bcl-2/Bax ratio. Recently, tanshinone IIA was demonstrated to induce cell death and apoptosis in a variety of tumors.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	294.34
Formula	C19H18O3
CAS No.	568-72-9

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Tanshinone B

Solubility (25°C) *	In vitro	DMSO	5 mg/mL (16.98 mM)
		Water	<1 mg/mL (
		Ethanol	<1 mg/mL (

Chemical Name	Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-

Stock Solution (1ml DMSO)	1mM	10mM	20mM	30mM
Mass(mg)	0.29434	2.9434	5.8868	8.8302

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