Ribavirin 36791-04-5

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Molecular Weight: 244.20864 Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses.


Biological Activity


Ribavirin significantly reduces the efficiency with which progeny
subgenomic replicons transfect new cells in the replicon system,
although ribavirin has little effect on levels of HCV replication.
Ribavirin increases the mutation frequency of HCV, with the highest
rates of mutations being found in the NS5A-encoding region. Ribavirin
enhances TH1 while inhibiting T 2 cytokine production by stimulated T
cells. Ribavirin shows antiviral activity against a variety of RNA
viruses and is used in combination with interferon-alpha to treat
hepatitis C virus infection. Ribavirin reduces infectious poliovirus
production to as little as 0. 00001% in cell culture.


Ribavirin's antiviral activity is exerted directly through lethal mutagenesis of the viral genetic material.
Ribavirin markedly reduces viral-induced parameters of macrophage
activation at physiologic concentrations (up to 500 mg/mL). Ribavirin
inhibits the production of IL-4 by Th2 cells, whereas it does not
diminish the production of IFN-gamma in Th1 cells. Ribavirin exhibits
antiviral activity against a broad range of both DNA and RNA viruses in
vitro. Ribavirin is a cytostatic agent and causes a reduction in
synthesis of DNA, RNA and Proteins in exposed cells. Ribavirin is
thought to induce a switch in T-helper cell phenotype from type 2 to
type 1.


Protocol(Only for Reference)


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	244.20864
Formula	C8H12N4O5
CAS No.	36791-04-5

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms

Solubility (25°C) *	In vitro	DMSO	49 mg/mL (200.64 mM)
		Water	49 mg/mL (200.64 mM)
		Ethanol	<1 mg/mL (

Chemical Name	1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

Stock Solution (1ml DMSO)	1mM	10mM	20mM	30mM
Mass(mg)	0.24420864	2.4420864	4.8841728	7.3262592

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