Sodium Danshensu 67920-52-9

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Molecular Weight:

220.15 Sodium Danshensu is a mono sodium of danshensu, which is a natural phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza.

Biological Activity

Sodium Danshensu is a mono sodium of danshensu which is a compound
isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical
scavenger and antioxidant which exhibits higher scavenging activities
against free hydroxyl radicals (HO()), superoxide anion radicals
(O(2)(-)), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and
2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than
vitamin C.


Sodium danshensu shows a biphasic effects on
vessel tension. In phenylephrine-precontracted thoracic arteries with or
without endothelium, low concentration (0.1-0.3 g/L) of sodium
danshensu produces a weak contraction, while high concentrations (1-3
g/L) produces a pronounced vasodilator after a transient
vasocontraction.


Pre-incubation with sodium danshensu could inhibit
vessel contraction induced by phenylephrine and potassium chloride in a
concentration-dependent way. Sodium danshensu also inhibits
phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium.


LD50: Mice 2356.33 mg/kg (i.g.); Rats >1500mg/kg (i.v.).

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