Naringin 10236-47-2

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Molecular Weight:

580.53 Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.






Biological Activity


Naringin is a flavanone glycoside, which gives the grapefruit juice its
bitter taste. Naringin inhibits hepatic P-glycoprotein (P-gp) and some
drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2,
which may result in drug-drug interactions.


Naringin is also an inhibitor of vascular endothelial growth factor (VEGF) release, which causes Angiogenesis. In addition, Naringin reduces diabetes-induced neuropathy in rats.


LD50: Mice 1650mg/kg.






Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Baboon	Dog	Monkey	Rabbit	Guinea pig	Rat	Hamster	Mouse
Weight (kg)	12	10	3	1.8	0.4	0.15	0.08	0.02
Body Surface Area (m2)	0.6	0.5	0.24	0.15	0.05	0.025	0.02	0.007
Km factor	20	20	12	12	8	6	5	3

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×	mouse Km(3)	= 11.2 mg/kg
	rat Km(6)

Chemical Information

Molecular Weight (MW)	580.53
Formula	C27H32O14
CAS No.	10236-47-2

Storage	3 years -20℃Powder
	6 months-80℃in solvent (DMSO, water, etc.)
Synonyms	Naringoside

Solubility (25°C) *	In vitro	DMSO	116 mg/mL (199.81 mM)
		Water	<1 mg/mL (
		Ethanol	2 mg/mL (3.44 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Name	4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-

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